The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity
PVR (poliovirus receptor) functions as a ligand that signals through TIGIT and CD96 to induce suppression of T-cell and NK-cell responses. Alternatively, PVR binds to CD226, resulting in a co-stimulatory signal. To date, TIGIT antibody antagonists have been developed to restore immune functions and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030575/ https://www.ncbi.nlm.nih.gov/pubmed/36944702 http://dx.doi.org/10.1038/s41598-023-30999-w |