Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival

BACKGROUND: Progression of colorectal cancer (CRC), a leading cause of cancer-related death worldwide, is driven by colorectal cancer stem cells (CR-CSCs), which are regulated by endogenous and microenvironmental signals. Interleukin (IL)-30 has proven to be crucial for CSC viability and tumor progr...

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Detalles Bibliográficos
Autores principales: D'Antonio, Luigi, Fieni, Cristiano, Ciummo, Stefania Livia, Vespa, Simone, Lotti, Lavinia, Sorrentino, Carlo, Di Carlo, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030651/
https://www.ncbi.nlm.nih.gov/pubmed/36927528
http://dx.doi.org/10.1136/jitc-2022-006056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030651/
https://www.ncbi.nlm.nih.gov/pubmed/36927528
http://dx.doi.org/10.1136/jitc-2022-006056

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