ClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation

Mycobacterium tuberculosis Clp proteases are targeted by several antitubercular compounds, including cyclomarin A (CymA). CymA exerts its toxicity by binding to AAA + chaperone ClpC1. Here, we show that CymA can also bind a partial homologue of ClpC1, known as ClpC2, and we reveal the molecular basi...

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Detalles Bibliográficos
Autores principales: Taylor, Gabrielle, Cui, Hengjun, Leodolter, Julia, Giese, Christoph, Weber-Ban, Eilika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030653/
https://www.ncbi.nlm.nih.gov/pubmed/36944713
http://dx.doi.org/10.1038/s42003-023-04658-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030653/
https://www.ncbi.nlm.nih.gov/pubmed/36944713
http://dx.doi.org/10.1038/s42003-023-04658-9

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