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Targeting FMRP: A new window for cancer immunotherapy
FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues. FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes. FMRP‐KO up‐regulates tumor cell secretion of CCL7, which directly activates and recrui...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030685/ https://www.ncbi.nlm.nih.gov/pubmed/36968189 http://dx.doi.org/10.1002/mco2.233 |