Targeting FMRP: A new window for cancer immunotherapy

FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues. FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes. FMRP‐KO up‐regulates tumor cell secretion of CCL7, which directly activates and recrui...

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Detalles Bibliográficos
Autores principales: Zhang, Yaguang, Wu, Tong, Han, Junhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030685/
https://www.ncbi.nlm.nih.gov/pubmed/36968189
http://dx.doi.org/10.1002/mco2.233
Descripción
Sumario:FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues. FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes. FMRP‐KO up‐regulates tumor cell secretion of CCL7, which directly activates and recruits CD8+ T cells. FMRP‐KO recruits CCR5 and CXCR4 receptor‐positive CD8 T cells indirectly by promoting M1 macrophages to secrete CCL5, CXCL9, and CXCL10. [Image: see text]

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