MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression

INTRODUCTION: The cell line MC38 is a commonly used murine model for colorectal carcinoma. It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and endogenous CD8+ T cell responses against neoantigens have been reported. METHODS: Here, we re-sequenced exomes and transcrip...

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Detalles Bibliográficos
Autores principales: Schrörs, Barbara, Hos, Brett J., Yildiz, Ikra G., Löwer, Martin, Lang, Franziska, Holtsträter, Christoph, Becker, Julia, Vormehr, Mathias, Sahin, Ugur, Ossendorp, Ferry, Diken, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030996/
https://www.ncbi.nlm.nih.gov/pubmed/36969213
http://dx.doi.org/10.3389/fimmu.2023.1102282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030996/
https://www.ncbi.nlm.nih.gov/pubmed/36969213
http://dx.doi.org/10.3389/fimmu.2023.1102282

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