Tissue-specific heteroplasmy segregation is accompanied by a sharp mtDNA decline in Caenorhabditis elegans soma

Mutations in the mitochondrial genome (mtDNA) can be pathogenic. Owing to the multi-copy nature of mtDNA, wild-type copies can compensate for the effects of mutant mtDNA. Wild-type copies available for compensation vary depending on the mutant load and the total copy number. Here, we examine both mu...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsyba, Nikita, Feng, Gaomin, Grub, Lantana K., Held, James P., Strozak, Adrianna M., Burkewitz, Kristopher, Patel, Maulik R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031119/
https://www.ncbi.nlm.nih.gov/pubmed/36968071
http://dx.doi.org/10.1016/j.isci.2023.106349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031119/
https://www.ncbi.nlm.nih.gov/pubmed/36968071
http://dx.doi.org/10.1016/j.isci.2023.106349

Ejemplares similares