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Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of hyperexcitability. However, it is still unknown how INs are functio...
Autores principales: | Kudo, Takehiro, Takuwa, Hiroyuki, Takahashi, Manami, Urushihata, Takuya, Shimojo, Masafumi, Sampei, Kazuaki, Yamanaka, Mitsugu, Tomita, Yutaka, Sahara, Naruhiko, Suhara, Tetsuya, Higuchi, Makoto |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031157/ https://www.ncbi.nlm.nih.gov/pubmed/36968086 http://dx.doi.org/10.1016/j.isci.2023.106342 |
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