Cargando…

Excitotoxic glutamate levels drive spinal cord ependymal stem cell proliferation and fate specification through CP-AMPAR signaling

The adult spinal cord contains a population of ependymal-derived neural stem/progenitor cells (epNSPCs) that are normally quiescent, but are activated to proliferate, differentiate, and migrate after spinal cord injury. The mechanisms that regulate their response to injury cues, however, remain unkn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hachem, Laureen D., Hong, James, Velumian, Alexander, Mothe, Andrea J., Tator, Charles H., Fehlings, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031285/ https://www.ncbi.nlm.nih.gov/pubmed/36764296 http://dx.doi.org/10.1016/j.stemcr.2023.01.005

Ejemplares similares

Effect of BDNF and Other Potential Survival Factors in Models of In Vitro Oxidative Stress on Adult Spinal Cord–Derived Neural Stem/Progenitor Cells
por: Hachem, Laureen D., et al.
Publicado: (2015)

The Impact of Spinal Cord Neuromodulation on Restoration of Walking Ability After Spinal Cord Injury
por: Fehlings, Michael G., et al.
Publicado: (2022)

Neuroplasticity and regeneration after spinal cord injury
por: Punjani, Nayaab, et al.
Publicado: (2023)

Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity
por: Wang, Min, et al.
Publicado: (2012)

Ghrelin Protects Spinal Cord Motoneurons Against Chronic Glutamate Excitotoxicity by Inhibiting Microglial Activation
por: Lee, Sungyoub, et al.
Publicado: (2012)

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
por: Meletis, Konstantinos, et al.
Publicado: (2008)

Musashi and Plasticity of Xenopus and Axolotl Spinal Cord Ependymal Cells
por: Chernoff, Ellen A. G., et al.
Publicado: (2018)

The activation of dormant ependymal cells following spinal cord injury
por: Rodriguez-Jimenez, Francisco Javier, et al.
Publicado: (2023)

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury
por: Ren, Yilong, et al.
Publicado: (2017)

The leading edge: Emerging neuroprotective and neuroregenerative cell‐based therapies for spinal cord injury
por: Ahuja, Christopher S., et al.
Publicado: (2020)

RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate
por: Chevreau, Robert, et al.
Publicado: (2021)

Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time
por: Li, Xiaofei, et al.
Publicado: (2016)

Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord
por: Nelson, Craig M., et al.
Publicado: (2019)

Meningeal Foam Cells and Ependymal Cells in Axolotl Spinal Cord Regeneration
por: Enos, Nathaniel, et al.
Publicado: (2019)

CCP1, a Tubulin Deglutamylase, Increases Survival of Rodent Spinal Cord Neurons following Glutamate-Induced Excitotoxicity
por: Ramadan, Yasmin H., et al.
Publicado: (2021)

Neural Stem/Progenitor Cells from the Adult Human Spinal Cord Are Multipotent and Self-Renewing and Differentiate after Transplantation
por: Mothe, Andrea J., et al.
Publicado: (2011)

Adult spinal cord ependymal layer: a promising pool of quiescent stem cells to treat spinal cord injury
por: Panayiotou, Elena, et al.
Publicado: (2013)

An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats
por: Lu, Cheng-Wei, et al.
Publicado: (2022)

Central Canal Ependymal Cells Proliferate Extensively in Response to Traumatic Spinal Cord Injury but Not Demyelinating Lesions
por: Lacroix, Steve, et al.
Publicado: (2014)

CB(1) cannabinoid receptor enrichment in the ependymal region of the adult human spinal cord
por: Paniagua-Torija, Beatriz, et al.
Publicado: (2015)

Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases
por: Ishikawa, Makoto
Publicado: (2013)

Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice
por: Miyajima, Hisao, et al.
Publicado: (2021)

GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord()
por: Corns, Laura F., et al.
Publicado: (2013)

Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation
por: Rodriguez-Jimenez, Francisco Javier, et al.
Publicado: (2015)

The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals
por: Torrillas de la Cal, Alejandro, et al.
Publicado: (2021)

Glutamate Excitotoxicity Inflicts Paranodal Myelin Splitting and Retraction
por: Fu, Yan, et al.
Publicado: (2009)

Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis
por: Takeda, Atsushi
Publicado: (2010)

Dopamine protects neurons against glutamate-induced excitotoxicity
por: Vaarmann, A, et al.
Publicado: (2013)

Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
por: Krasil’nikova, Irina, et al.
Publicado: (2019)

Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity
por: Zgodova, Arina, et al.
Publicado: (2022)

Enhanced incentive motivation in obesity-prone rats is mediated by NAc core CP-AMPARs
por: Derman, Rifka C., et al.
Publicado: (2017)

Using MRI to predict the fate of excitotoxic lesions in rats
por: Cholvin, Thibault, et al.
Publicado: (2018)

Evidence for AMPAR association
por: Tuma, Rabiya S.
Publicado: (2005)

Evaluation of the sodium-glutamate blocker riluzole in a preclinical model of ervical spinal cord injury
por: Wu, Yongchao, et al.
Publicado: (2010)

Development of a Systems Medicine Approach to Spinal Cord Injury
por: Guest, James D., et al.
Publicado: (2023)

Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake
por: Gentile, Antonietta, et al.
Publicado: (2018)

Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity
por: Gonçalves-Ribeiro, Joana, et al.
Publicado: (2019)

Astrocytes enhance the tolerance of rat cortical neurons to glutamate excitotoxicity
por: Zhang, Li-Nan, et al.
Publicado: (2019)

Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells
por: Belov Kirdajova, Denisa, et al.
Publicado: (2020)

Remimazolam induced cognitive dysfunction in mice via glutamate excitotoxicity
por: Zhou, Xin-hua, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6f6datl3io4p75f45r950o3oh2