A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal enzyme in the Toll-like receptor (TLR)/MYD88 dependent signaling pathway, which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL). Inflammatory responses followed by...

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Detalles Bibliográficos
Autores principales: Yoon, Sae-Bom, Hong, Hyowon, Lim, Hee-Jong, Choi, Ji Hye, Choi, Yoon Pyo, Seo, Seong Wook, Lee, Hyuk Woo, Chae, Chong Hak, Park, Woo-Kyu, Kim, Hyun Young, Jeong, Daeyoung, De, Tran Quang, Myung, Chang-Seon, Cho, Heeyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031381/
https://www.ncbi.nlm.nih.gov/pubmed/36970199
http://dx.doi.org/10.1016/j.apsb.2022.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031381/
https://www.ncbi.nlm.nih.gov/pubmed/36970199
http://dx.doi.org/10.1016/j.apsb.2022.12.001

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