Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine

The dedicator of cytokinesis 2(DOCK2) protein, an atypical guanine nucleotide exchange factor (GEFs), is a member of the DOCKA protein subfamily. DOCK2 protein deficiency is characterized by early-onset lymphopenia, recurrent infections, and lymphocyte dysfunction, which was classified as combined i...

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Detalles Bibliográficos
Autores principales: Li, Wenhui, Sun, Yuting, Yu, Lang, Chen, Ran, Gan, Rui, Qiu, Luyao, Sun, Gan, Chen, Junjie, Zhou, Lina, Ding, Yuan, Du, Hongqiang, Shu, Zhou, Zhang, Zhiyong, Tang, Xuemei, Chen, Yongwen, Zhao, Xiaodong, Zhao, Qin, An, Yunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032263/
https://www.ncbi.nlm.nih.gov/pubmed/36947335
http://dx.doi.org/10.1007/s10875-023-01466-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032263/
https://www.ncbi.nlm.nih.gov/pubmed/36947335
http://dx.doi.org/10.1007/s10875-023-01466-y

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