Inflammation and Blood-Brain Barrier in Depression: Interaction of CLDN5 and IL6 Gene Variants in Stress-Induced Depression

BACKGROUND: Evidence from rodents indicated that after recent stress, reduced expression of tight junction protein claudin-5 may weaken the blood-brain barrier and allow interleukin-6 to induce depressive symptoms. Our aims were to prove this pathomechanism in humans. METHODS: We used a large popula...

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Detalles Bibliográficos
Autores principales: Gal, Zsofia, Torok, Dora, Gonda, Xenia, Eszlari, Nora, Anderson, Ian Muir, Deakin, Bill, Juhasz, Gabriella, Bagdy, Gyorgy, Petschner, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032304/
https://www.ncbi.nlm.nih.gov/pubmed/36472886
http://dx.doi.org/10.1093/ijnp/pyac079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032304/
https://www.ncbi.nlm.nih.gov/pubmed/36472886
http://dx.doi.org/10.1093/ijnp/pyac079

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