Cargando…

Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

DNA methylation has emerged as a critical modulator of neuronal plasticity and cognitive function. Notwithstanding, the role of enzymes that demethylate DNA remain to be fully explored. Here, we report that loss of ten-eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes oxidati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pratt, Karishma J.B., Shea, Jeremy M., Remesal-Gomez, Laura, Bieri, Gregor, Smith, Lucas K., Couthouis, Julien, Chen, Christopher P., Roy, Irena J., Gontier, Geraldine, Villeda, Saul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032941/ https://www.ncbi.nlm.nih.gov/pubmed/36351399 http://dx.doi.org/10.1016/j.celrep.2022.111612

Ejemplares similares

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain
por: Gontier, Geraldine, et al.
Publicado: (2018)

Neuronal activation of G(αq) EGL-30/GNAQ late in life rejuvenates cognition across species
por: Stevenson, Morgan E., et al.
Publicado: (2023)

Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation
por: White, Charles W., et al.
Publicado: (2020)

MHC class I H2-K(b) negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling
por: Lin, Karin, et al.
Publicado: (2021)

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain
por: Wheatley, Elizabeth G., et al.
Publicado: (2019)

The aged hematopoietic system promotes hippocampal‐dependent cognitive decline
por: Smith, Lucas K., et al.
Publicado: (2020)

Platelet factors attenuate inflammation and rescue cognition in ageing
por: Schroer, Adam B., et al.
Publicado: (2023)

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
por: Smith, Lucas K., et al.
Publicado: (2015)

Platelets Give a Running Start to Adult Hippocampal Neurogenesis
por: Schroer, Adam B., et al.
Publicado: (2019)

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
por: Leiter, Odette, et al.
Publicado: (2023)

Loss of TET2 and TET3 in regulatory T cells unleashes effector function
por: Yue, Xiaojing, et al.
Publicado: (2019)

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
por: Bieri, Gregor, et al.
Publicado: (2018)

Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice
por: Jessop, Peter, et al.
Publicado: (2018)

Microglia communication: Parallels between aging and Alzheimer's disease
por: Udeochu, Joe C., et al.
Publicado: (2016)

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
por: Bieri, Gregor, et al.
Publicado: (2019)

TET2 and TET3 loss disrupts small intestine differentiation and homeostasis
por: Ansari, Ihab, et al.
Publicado: (2023)

Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits
por: Yu, Diankun, et al.
Publicado: (2022)

Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury
por: Luo, Jian, et al.
Publicado: (2014)

Corrigendum: Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury
por: Luo, Jian, et al.
Publicado: (2022)

Loss of nuclear localization of TET2 in colorectal cancer
por: Huang, Yuji, et al.
Publicado: (2016)

MECHANISMS OF BRAIN REJUVENATION
por: Villeda, Saul
Publicado: (2019)

Regeneration and Cognition in Aging
por: Villeda, Saul
Publicado: (2020)

Systemic Mechanisms of Brain Rejuvenation
por: Villeda, Saul
Publicado: (2021)

Healthy Brain Aging
por: Villeda, Saul
Publicado: (2021)

Loss of Tet2 affects platelet function but not coagulation in mice
Publicado: (2022)

Loss of Tet2 affects platelet function but not coagulation in mice
por: Wang, Bichen, et al.
Publicado: (2020)

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker
por: Pantier, Raphaël, et al.
Publicado: (2019)

TET2 binds the androgen receptor and loss is associated with prostate cancer
por: Nickerson, ML, et al.
Publicado: (2016)

These violent repeats have violent extends
por: Couthouis, Julien, et al.
Publicado: (2018)

Hippocampal sclerosis, hippocampal neuron loss patterns and TDP‐43 in the aged population
por: Hokkanen, Suvi R. K., et al.
Publicado: (2017)

TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2(−/−)-Driven Myeloid Malignancy Progression
por: Li, Rong, et al.
Publicado: (2017)

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity
por: Kramer, Nicholas J., et al.
Publicado: (2018)

Acute loss of TET function results in aggressive myeloid cancer in mice
por: An, Jungeun, et al.
Publicado: (2015)

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
por: Pan, Feng, et al.
Publicado: (2017)

The systemic environment: at the interface of aging and adult neurogenesis
por: Smith, Lucas K., et al.
Publicado: (2017)

Hyperbaric Oxygenation Prevents Loss of Immature Neurons in the Adult Hippocampal Dentate Gyrus Following Brain Injury
por: Jeremic, Rada, et al.
Publicado: (2023)

Cognitive Aging: New Insights Into How Our Brains Age
por: Murphy, Coleen, et al.
Publicado: (2020)

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders
por: Muto, Tomoya, et al.
Publicado: (2013)

Il-1r1 drives leukemogenesis induced by Tet2 loss
por: Burns, Sarah S., et al.
Publicado: (2022)

Nanog-dependent function of Tet1 and Tet2 in establishment of pluripotency
por: Costa, Yael, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_g2v47n9d5t3iqlli8c40uca5d7