Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281

The human oxysterol 12α-hydroxylase cytochrome P450 8B1 (CYP8B1) is a validated drug target for both type 2 diabetes and nonalcoholic fatty liver disease, but effective selective inhibitors are not yet available. Herein, steroidal substrate-mimicking compounds with a pyridine ring appended to the C1...

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Detalles Bibliográficos
Autores principales: Liu, Jinghan, Offei, Samuel D., Yoshimoto, Francis K., Scott, Emily E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033310/
https://www.ncbi.nlm.nih.gov/pubmed/36806682
http://dx.doi.org/10.1016/j.jbc.2023.103032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033310/
https://www.ncbi.nlm.nih.gov/pubmed/36806682
http://dx.doi.org/10.1016/j.jbc.2023.103032

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