Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade

Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 T cell mediated killing are less understood. Kinases are potentially druggable targets that drive tumor progression an...

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Detalles Bibliográficos
Autores principales: Dmello, Crismita, Zhao, Junfei, Chen, Li, Gould, Andrew, Castro, Brandyn, Arrieta, Victor A., Zhang, Daniel Y., Kim, Kwang-Soo, Kanojia, Deepak, Zhang, Peng, Miska, Jason, Yeeravalli, Ragini, Habashy, Karl, Saganty, Ruth, Kang, Seong Jae, Fares, Jawad, Liu, Connor, Dunn, Gavin, Bartom, Elizabeth, Schipma, Matthew J., Hsu, Patrick D., Alghamri, Mahmoud S., Lesniak, Maciej S., Heimberger, Amy B., Rabadan, Raul, Lee-Chang, Catalina, Sonabend, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033639/
https://www.ncbi.nlm.nih.gov/pubmed/36949040
http://dx.doi.org/10.1038/s41467-023-36878-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033639/
https://www.ncbi.nlm.nih.gov/pubmed/36949040
http://dx.doi.org/10.1038/s41467-023-36878-2

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