The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression

Trypanosoma brucei is a protozoan parasite that causes human African trypanosomiasis. Its major surface antigen VSG is expressed from subtelomeric loci in a strictly monoallelic manner. We previously showed that the telomere protein TbRAP1 binds dsDNA through its (737)RKRRR(741) patch to silence VSG...

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Detalles Bibliográficos
Autores principales: Gaurav, Amit Kumar, Afrin, Marjia, Yang, Xian, Saha, Arpita, Sayeed, S. K. Abdus, Pan, Xuehua, Ji, Zeyang, Wong, Kam-Bo, Zhang, Mingjie, Zhao, Yanxiang, Li, Bibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033678/
https://www.ncbi.nlm.nih.gov/pubmed/36949076
http://dx.doi.org/10.1038/s41467-023-37307-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033678/
https://www.ncbi.nlm.nih.gov/pubmed/36949076
http://dx.doi.org/10.1038/s41467-023-37307-0

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