Cargando…

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are currently incurable, while human pluripotent stem cells (hPSCs)-derived spinal motor neurons are p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, He Jax, Yao, Yao, Yao, Fenyong, Chen, Jiehui, Li, Meishi, Yang, Xianfa, Li, Sheng, Lu, Fangru, Hu, Ping, He, Shuijin, Peng, Guangdun, Jing, Naihe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033800/ https://www.ncbi.nlm.nih.gov/pubmed/36949352 http://dx.doi.org/10.1186/s13619-023-00159-6

Ejemplares similares

Endothelial and hematopoietic hPSCs differentiation via a hematoendothelial progenitor
por: Vargas-Valderrama, Alejandra, et al.
Publicado: (2022)

SIX1(+)PAX3(+) identify a progenitor for myogenic lineage commitment from hPSCs
por: Jaime, Olga G., et al.
Publicado: (2023)

Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord‐Like Organoid (pSCO) with Dorsoventral Organization
por: Seo, Kyubin, et al.
Publicado: (2023)

PINE-TREE enables efficient enrichment of prime-edited hPSCs
por: Jia, Mary S., et al.
Publicado: (2023)

Directed differentiation of hPSCs through a simplified lateral plate mesoderm protocol for generation of articular cartilage progenitors
por: Smith, Christopher A., et al.
Publicado: (2023)

Maintenance of hPSCs under Xeno-Free and Chemically Defined Culture Conditions
por: Lim, Jung Jin, et al.
Publicado: (2019)

Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
por: Zhu, Wenliang, et al.
Publicado: (2019)

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
por: Shi, Zhong-Dong, et al.
Publicado: (2017)

Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs
por: Valiulahi, Parvin, et al.
Publicado: (2021)

Single-cell qPCR facilitates the optimization of hematopoietic differentiation in hPSCs/OP9 coculture system
por: Chen, Haide, et al.
Publicado: (2018)

Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation
por: Teo, Adrian Kee Keong, et al.
Publicado: (2021)

Mapping germ-layer specification preventing genes in hPSCs via genome-scale CRISPR screening
por: Xu, Xiangjie, et al.
Publicado: (2020)

ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway
por: Li, Shasha, et al.
Publicado: (2023)

Effective derivation of ventricular cardiomyocytes from hPSCs using ascorbic acid-containing maturation medium
por: Kim, Ji-eun, et al.
Publicado: (2023)

Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma
por: Samuel, Ryan M., et al.
Publicado: (2023)

The State of Play with iPSCs and Spinal Cord Injury Models
por: Hodgetts, Stuart I., et al.
Publicado: (2015)

Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs
por: Shen, Pei, et al.
Publicado: (2022)

Protocol for genome-scale CRISPR screening in engineered lineage reporter hPSCs to study cell fate determination
por: Zhou, Zhongshu, et al.
Publicado: (2021)

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs
por: Bertero, Alessandro, et al.
Publicado: (2016)

MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME
por: Zhang, Leisheng, et al.
Publicado: (2018)

De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs
por: Motosugi, Nami, et al.
Publicado: (2022)

Comparison of Anterior and Posterior Decompressions in Treatment of Traumatic Thoracolumbar Spinal Fractures Complicated with Spinal Cord Injury
por: Yao, Yilun, et al.
Publicado: (2020)

Guiding migration of transplanted glial progenitor cells in the injured spinal cord
por: Yuan, Xiao-bing, et al.
Publicado: (2016)

Neuromesodermal progenitors and the making of the spinal cord
por: Henrique, Domingos, et al.
Publicado: (2015)

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition
por: Ordovás, Laura, et al.
Publicado: (2015)

Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions
por: Hackland, James O.S., et al.
Publicado: (2017)

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition
por: Ordovás, Laura, et al.
Publicado: (2018)

miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro
por: Ishikawa, Mitsuru, et al.
Publicado: (2020)

Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification
por: Maurya, Shailendra, et al.
Publicado: (2021)

Relationship between Spinal Cord Volume and Spinal Cord Injury due to Spinal Shortening
por: Qiu, Feng, et al.
Publicado: (2015)

Standardization of Cell Culture Conditions and Routine Genomic Screening under a Quality Management System Leads to Reduced Genomic Instability in hPSCs
por: Molina-Ruiz, Francisco J., et al.
Publicado: (2022)

The Role of GABA in Spinal Cord Injury
por: Yao, Xue
Publicado: (2022)

The Efficacy of Anterior Cervical Corpectomy and Fusion and Posterior Total Laminectomy on Cervical Spinal Cord Injury and Quality of Life
por: Yin, Yanlin, et al.
Publicado: (2022)

Bone Cement and Pedicle Screw for the Treatment of Spinal Tumors with Spinal Cord Compression and Posterior Wall Defects
por: Shao, Xiaofeng, et al.
Publicado: (2022)

Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons
por: Castillo Bautista, Cristina Marisol, et al.
Publicado: (2023)

Organotypic Spinal Cord Slice Culture to Study Neural Stem/Progenitor Cell Microenvironment in the Injured Spinal Cord
por: Kim, Hyuk Min, et al.
Publicado: (2010)

C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors
por: He, Di Demi, et al.
Publicado: (2020)

Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord
por: Rabadán, M A, et al.
Publicado: (2012)

Posterior spinal decompression in adults with spinal cord injury without traumatic compromise of the spinal canal: what is the data?
por: Solou, Mary, et al.
Publicado: (2023)

Regenerating the Injured Spinal Cord at the Chronic Phase by Engineered iPSCs‐Derived 3D Neuronal Networks
por: Wertheim, Lior, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_479n6bb3rh0t0jtg4ksjh2ucet