NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice

In mammalian mitochondria, translation of the AUA codon is supported by 5-formylcytidine (f(5)C) modification in the mitochondrial methionine tRNA anticodon. The 5-formylation is initiated by NSUN3 methylase. Human NSUN3 mutations are associated with mitochondrial diseases. Here we show that Nsun3 i...

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Detalles Bibliográficos
Autores principales: Murakami, Yoshitaka, Wei, Fan-Yan, Kawamura, Yoshimi, Horiguchi, Haruki, Kadomatsu, Tsuyoshi, Miyata, Keishi, Miura, Kyoko, Oike, Yuichi, Ando, Yukio, Ueda, Mitsuharu, Tomizawa, Kazuhito, Chujo, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033821/
https://www.ncbi.nlm.nih.gov/pubmed/36949224
http://dx.doi.org/10.1038/s42003-023-04680-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033821/
https://www.ncbi.nlm.nih.gov/pubmed/36949224
http://dx.doi.org/10.1038/s42003-023-04680-x

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