Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease

Calcium dynamics in astrocytes represent a fundamental signal that through gliotransmitter release regulates synaptic plasticity and behaviour. Here we present a longitudinal study in the PS2APP mouse model of Alzheimer’s disease (AD) linking astrocyte Ca(2+) hypoactivity to memory loss. At the onse...

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Detalles Bibliográficos
Autores principales: Lia, Annamaria, Sansevero, Gabriele, Chiavegato, Angela, Sbrissa, Miriana, Pendin, Diana, Mariotti, Letizia, Pozzan, Tullio, Berardi, Nicoletta, Carmignoto, Giorgio, Fasolato, Cristina, Zonta, Micaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033875/
https://www.ncbi.nlm.nih.gov/pubmed/36949142
http://dx.doi.org/10.1038/s41467-023-37240-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033875/
https://www.ncbi.nlm.nih.gov/pubmed/36949142
http://dx.doi.org/10.1038/s41467-023-37240-2

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