Cargando…

NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein

NTSR1 abnormal expression by cancer cells makes it a strategic target for antitumoral therapies, such as compounds that use NTSR1 binding probes to deliver cytotoxic agents to tumor cells. Success of these therapies relies on NTSR1 protein availability and accessibility; therefore, understanding the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Libanje, Fotine, Delille, Raphael, Young, Pamela A, Rolland, Sylvie, Meyer-Losic, Florence, Lewkowicz, Elodie, Klinz, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033925/ https://www.ncbi.nlm.nih.gov/pubmed/36949141 http://dx.doi.org/10.1038/s41598-023-31790-7

Ejemplares similares

Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice
por: Devader, Christelle, et al.
Publicado: (2016)

Neurotensin Receptor 1 Gene (NTSR1) Polymorphism Is Associated with Working Memory
por: Li, Jin, et al.
Publicado: (2011)

Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors
por: Kamimae, Seiko, et al.
Publicado: (2015)

Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients
por: Ouyang, Qing, et al.
Publicado: (2015)

The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in the Membrane Expression of TREK-1
por: Mazella, Jean, et al.
Publicado: (2019)

Correction: Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients
por: Ouyang, Qing, et al.
Publicado: (2022)

Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice
por: Ehrlich, Aliza T., et al.
Publicado: (2022)

Augmenting Experimental Gastric Cancer Activity of Irinotecan through Liposomal Formulation and Antiangiogenic Combination Therapy
por: Awasthi, Niranjan, et al.
Publicado: (2022)

NTS, NTSR1 and ERs in the Pituitary–Gonadal Axis of Cycling and Postnatal Female Rats after BPA Treatment
por: González-Gómez, Miriam, et al.
Publicado: (2023)

Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage
por: Hingorani, Dina V., et al.
Publicado: (2018)

LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
por: Chen, Yi-Ling, et al.
Publicado: (2023)

Generation of Matrix Degradation Products Using an In Vitro MMP Cleavage Assay
por: Wagner, Niklas, et al.
Publicado: (2022)

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
por: Zhang, Liping, et al.
Publicado: (2021)

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
por: Zhang, Liping, et al.
Publicado: (2021)

A Comparative Study of Fibronectin Cleavage by MMP-1, -3, -13, and -14
por: Zhang, Xiaorong, et al.
Publicado: (2012)

Computational design of Matrix Metalloproteinase-9 (MMP-9) resistant to auto-cleavage
por: Bonadio, Alessandro, et al.
Publicado: (2023)

Cleavage of periostin by MMP9 protects mice from kidney cystic disease
por: Djaziri, Nabila, et al.
Publicado: (2023)

Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
por: Rosen, Laura E., et al.
Publicado: (2019)

Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton
por: Tarbet, Heather J, et al.
Publicado: (2018)

MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis
por: Williams, Helen, et al.
Publicado: (2010)

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib
por: Younes, Mohamad, et al.
Publicado: (2014)

Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model
por: Perepelyuk, Maryna, et al.
Publicado: (2016)

Liposomal Irinotecan Shows a Larger Therapeutic Index than Non-liposomal Irinotecan in Patient-Derived Xenograft Models of Pancreatic Cancer
por: Barbier, Sandrine, et al.
Publicado: (2023)

Membrane biogenesis. In vitro cleavage, core glycosylation, and integration into microsomal membranes of sindbis virus glycoproteins
Publicado: (1979)

The Recognition of Collagen and Triple-helical Toolkit Peptides by MMP-13: SEQUENCE SPECIFICITY FOR BINDING AND CLEAVAGE
por: Howes, Joanna-Marie, et al.
Publicado: (2014)

Cleavage by MMP‐13 renders VWF unable to bind to collagen but increases its platelet reactivity
por: Howes, Joanna‐Marie, et al.
Publicado: (2020)

MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations
por: Bartlett, John D., et al.
Publicado: (2021)

Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor
por: Guo, Xuanming, et al.
Publicado: (2022)

Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression
por: Ikeda, Kazuki, et al.
Publicado: (2022)

MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts
por: Zhang, Yuanbao, et al.
Publicado: (2023)

Electrochemical monitoring of enzymatic cleavage in nanochannels with nanoparticle-based enhancement: determination of MMP-9 biomarker
por: Valero-Calvo, David, et al.
Publicado: (2023)

Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study
por: Kumar, Sonu, et al.
Publicado: (2018)

Novel glycosyl prodrug of RXP03 as MMP-11 prodrug: design, synthesis and virtual screening
por: Abdou, Moaz M., et al.
Publicado: (2023)

MMP‐2 and MMP‐14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose‐Derived Mesenchymal Stem Cells to Endothelial Cells
por: Almalki, Sami G., et al.
Publicado: (2017)

Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles
por: Jia, Qiangqiang, et al.
Publicado: (2014)

Correlation of glycosylation forms with position in amino acid sequence
Publicado: (1983)

Crystal Structure of an Active Form of Human MMP-1
por: Iyer, Shalini, et al.
Publicado: (2006)

O-glycosylated pro-B-type natriuretic peptide is cleaved intracellularly by furin in ventricular and atrial myocytes: importance of the distance between the O-glycosylation and cleavage sites
por: Nishikimi, Toshio, et al.
Publicado: (2013)

β(1)-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes
por: Park, Misun, et al.
Publicado: (2017)

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage
por: Tian, Li, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_bd5uf8iusbu5895nefrb87ul35