PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection.

The potential gain in efficacy of pulmonary administration over IV administration of some antibiotics such as ciprofloxacin (CIP) may be limited by the short residence time of the drug at the site of infection after nebulization. Complexation of CIP with copper reduced its apparent permeability in v...

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Detalles Bibliográficos
Autores principales: Tewes, Frederic, Lamy, Barbara, Laroche, Julian, Lamarche, Isabelle, Marchand, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033950/
https://www.ncbi.nlm.nih.gov/pubmed/36970713
http://dx.doi.org/10.1016/j.ijpx.2023.100178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033950/
https://www.ncbi.nlm.nih.gov/pubmed/36970713
http://dx.doi.org/10.1016/j.ijpx.2023.100178

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