Cargando…

Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

INTRODUCTION: The apelin receptor binds two distinct endogenous peptides, apelin and ELA, which act in an autocrine/paracrine manner to regulate the human cardiovascular system. As a class A GPCR, targeting the apelin receptor is an attractive therapeutic strategy. With improvements in imaging techn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Thomas L., Macrae, Robyn G. C., Kuc, Rhoda E., Brown, Alastair J. H., Maguire, Janet J., Davenport, Anthony P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034064/ https://www.ncbi.nlm.nih.gov/pubmed/36967803 http://dx.doi.org/10.3389/fendo.2023.1139121

Ejemplares similares

Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor
por: Nyimanu, Duuamene, et al.
Publicado: (2019)

International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand
por: Read, Cai, et al.
Publicado: (2019)

Inducible apelin receptor knockdown reduces differentiation efficiency and contractility of hESC-derived cardiomyocytes
por: Macrae, Robyn G C, et al.
Publicado: (2022)

Cardiac action of the first G protein biased small molecule apelin agonist
por: Read, Cai, et al.
Publicado: (2016)

[Pyr(1)]Apelin-13((1–12)) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr(1)]Apelin-13
por: Yang, Peiran, et al.
Publicado: (2017)

Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function
por: Nyimanu, Duuamene, et al.
Publicado: (2022)

Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10
por: Owen, Nicola E., et al.
Publicado: (2021)

The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo
por: Read, Cai, et al.
Publicado: (2021)

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr(1)]apelin-13 in humans
por: Nyimanu, Duuamene, et al.
Publicado: (2019)

A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension
por: Yang, Peiran, et al.
Publicado: (2019)

The therapeutic potential of apelin in kidney disease
por: Chapman, Fiona A., et al.
Publicado: (2021)

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system
por: Yang, Peiran, et al.
Publicado: (2015)

Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites
por: Williams, Thomas L., et al.
Publicado: (2021)

Apelin and Apelin Receptor in Follicular Granulosa Cells of Buffalo Ovaries: Expression and Regulation of Steroidogenesis
por: Shokrollahi, Borhan, et al.
Publicado: (2022)

Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders
por: Flahault, Adrien, et al.
Publicado: (2017)

On Methods for the Measurement of the Apelin Receptor Ligand Apelin
por: Janssens, Peter, et al.
Publicado: (2022)

In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA
por: Nyimanu, Duuamene, et al.
Publicado: (2021)

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
por: Yang, Peiran, et al.
Publicado: (2017)

Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts
por: Zhang, Jiannan, et al.
Publicado: (2018)

Apelin and Vasopressin: The Yin and Yang of Water Balance
por: Girault-Sotias, Pierre-Emmanuel, et al.
Publicado: (2021)

The Role of Apelin–APJ System in Diabetes and Obesity
por: Li, Cheng, et al.
Publicado: (2022)

Pharmacological targeting of apelin impairs glioblastoma growth
por: Harford-Wright, Elizabeth, et al.
Publicado: (2017)

Possible roles of exercise and apelin against pregnancy complications
por: Alizadeh Pahlavani, Hamed
Publicado: (2022)

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
por: Jiang, Yunlu, et al.
Publicado: (2021)

Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention
por: Abraham, George R., et al.
Publicado: (2022)

Fish Feed Intake, Feeding Behavior, and the Physiological Response of Apelin to Fasting and Refeeding
por: Assan, Daniel, et al.
Publicado: (2021)

Secondary hormonal alterations in short-term severe hypothyroidism; in the focus: Apelin and copeptin
por: Gergics, Marin, et al.
Publicado: (2022)

Expanding role for the apelin/APJ system in physiopathology
por: Carpéné, C., et al.
Publicado: (2007)

Circulating apelin and chemerin levels in patients with polycystic ovary syndrome: A meta-analysis
por: Gao, Yiming, et al.
Publicado: (2023)

Expanding the UniFrac Toolbox
por: Wong, Ruth G., et al.
Publicado: (2016)

The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro
por: Maguire, Janet J., et al.
Publicado: (2014)

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
por: Williams, Thomas L., et al.
Publicado: (2021)

(-)-Epicatechin Is a Biased Ligand of Apelin Receptor
por: Portilla-Martínez, Andrés, et al.
Publicado: (2022)

Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension
por: Kuc, Rhoda E., et al.
Publicado: (2014)

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist
por: Brame, Aimee L., et al.
Publicado: (2015)

Xenopus Models of Cancer: Expanding the Oncologist’s Toolbox
por: Hardwick, Laura J. A., et al.
Publicado: (2018)

Developing an expanded vector control toolbox for malaria elimination
por: Killeen, Gerry F, et al.
Publicado: (2017)

The Expanding Toolbox of In Vivo Bioluminescent Imaging
por: Xu, Tingting, et al.
Publicado: (2016)

Expanding the toolbox to combat a pandemic
por: Prockop, Susan E.
Publicado: (2020)

Inotropic Action of the Puberty Hormone Kisspeptin in Rat, Mouse and Human: Cardiovascular Distribution and Characteristics of the Kisspeptin Receptor
por: Maguire, Janet J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jminmp2k5ms21fq5cggckk6vuq