Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation

Introduction: Hyperphosphorylated Tau protein (PPTau) is the hallmark of tauopathic neurodegeneration. During “synthetic torpor” (ST), a transient hypothermic state which can be induced in rats by the local pharmacological inhibition of the Raphe Pallidus, a reversible brain Tau hyperphosphorylation...

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Detalles Bibliográficos
Autores principales: Squarcio, Fabio, Hitrec, Timna, Piscitiello, Emiliana, Cerri, Matteo, Giovannini, Catia, Martelli, Davide, Occhinegro, Alessandra, Taddei, Ludovico, Tupone, Domenico, Amici, Roberto, Luppi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034179/
https://www.ncbi.nlm.nih.gov/pubmed/36969585
http://dx.doi.org/10.3389/fphys.2023.1129278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034179/
https://www.ncbi.nlm.nih.gov/pubmed/36969585
http://dx.doi.org/10.3389/fphys.2023.1129278

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