Unveiling the methyl transfer mechanisms in the epigenetic machinery DNMT3A-3 L: A comprehensive study integrating assembly dynamics with catalytic reactions

In epigenetic mechanisms, DNA methyltransferase 3 alpha (DNMT3A) acts as an initiator for DNA methylation and prevents the downstream genes from expressing. Perturbations of DNMT3A functions may cause uncontrolled gene expression, resulting in pathogenic consequences such as cancers. It is, therefor...

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Detalles Bibliográficos
Autores principales: Yang, Wei, Zhuang, Jingyuan, Li, Chen, Cheng, Gui-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034213/
https://www.ncbi.nlm.nih.gov/pubmed/36968013
http://dx.doi.org/10.1016/j.csbj.2023.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034213/
https://www.ncbi.nlm.nih.gov/pubmed/36968013
http://dx.doi.org/10.1016/j.csbj.2023.03.002

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