An AKT1-and TRIM21-mediated phosphodegron controls proteasomal degradation of HuR enabling cell survival under heat shock

Post-transcriptional regulation by RNA-binding proteins (RBPs) is a major mode of controlling gene expression under stress conditions. The RBP HuR regulates the translation/turnover of multiple mRNAs in stress responses. HuR is degraded in response to heat stress consequent to ubiquitination of the...

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Detalles Bibliográficos
Autores principales: Nag, Sharanya, Rahaman, Sayanur, Guha, Abhishek, Ray, Partho Sarothi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034463/
https://www.ncbi.nlm.nih.gov/pubmed/36968077
http://dx.doi.org/10.1016/j.isci.2023.106307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034463/
https://www.ncbi.nlm.nih.gov/pubmed/36968077
http://dx.doi.org/10.1016/j.isci.2023.106307

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