The Pseudomonas aeruginosa PAO1 metallo flavoprotein d-2-hydroxyglutarate dehydrogenase requires Zn(2+) for substrate orientation and activation

Pseudomonas aeruginosa PAO1 d-2-hydroxyglutarate (D2HG) dehydrogenase (PaD2HGDH) oxidizes D2HG to 2-ketoglutarate during the vital l-serine biosynthesis and is a potential therapeutic target against P. aeruginosa. PaD2HGDH, which oxidizes d-malate as an alternative substrate, has been demonstrated t...

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Detalles Bibliográficos
Autores principales: Quaye, Joanna A., Gadda, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034468/
https://www.ncbi.nlm.nih.gov/pubmed/36775127
http://dx.doi.org/10.1016/j.jbc.2023.103008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034468/
https://www.ncbi.nlm.nih.gov/pubmed/36775127
http://dx.doi.org/10.1016/j.jbc.2023.103008

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