Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis

We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4. The parasite was sequenced from an immun...

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Autores principales: Holbrook, Nolan R, Klontz, Erik H, Adams, Gordon C, Schnittman, Samuel R, Issa, Nicolas C, Bond, Sheila A, Branda, John A, Lemieux, Jacob E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034591/
https://www.ncbi.nlm.nih.gov/pubmed/36968958
http://dx.doi.org/10.1093/ofid/ofad097
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author Holbrook, Nolan R
Klontz, Erik H
Adams, Gordon C
Schnittman, Samuel R
Issa, Nicolas C
Bond, Sheila A
Branda, John A
Lemieux, Jacob E
author_facet Holbrook, Nolan R
Klontz, Erik H
Adams, Gordon C
Schnittman, Samuel R
Issa, Nicolas C
Bond, Sheila A
Branda, John A
Lemieux, Jacob E
author_sort Holbrook, Nolan R
collection PubMed
description We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4. The parasite was sequenced from an immunocompromised patient on prophylactic atovaquone for Pneumocystis pneumonia before diagnosis of babesiosis.
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spelling pubmed-100345912023-03-24 Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis Holbrook, Nolan R Klontz, Erik H Adams, Gordon C Schnittman, Samuel R Issa, Nicolas C Bond, Sheila A Branda, John A Lemieux, Jacob E Open Forum Infect Dis Brief Report We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4. The parasite was sequenced from an immunocompromised patient on prophylactic atovaquone for Pneumocystis pneumonia before diagnosis of babesiosis. Oxford University Press 2023-02-23 /pmc/articles/PMC10034591/ /pubmed/36968958 http://dx.doi.org/10.1093/ofid/ofad097 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Holbrook, Nolan R
Klontz, Erik H
Adams, Gordon C
Schnittman, Samuel R
Issa, Nicolas C
Bond, Sheila A
Branda, John A
Lemieux, Jacob E
Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
title Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
title_full Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
title_fullStr Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
title_full_unstemmed Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
title_short Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
title_sort babesia microti variant with multiple resistance mutations detected in an immunocompromised patient receiving atovaquone prophylaxis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034591/
https://www.ncbi.nlm.nih.gov/pubmed/36968958
http://dx.doi.org/10.1093/ofid/ofad097
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