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First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection
A double‐stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin‐producing Pseudomonas aeruginosa strain, which was isolated from a 40‐year‐old man with interstitial lung disease (ILD) and chronic lung infection. Phage therapy was used as a last resort for this patient. The three‐course nebuli...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034620/ https://www.ncbi.nlm.nih.gov/pubmed/36636832 http://dx.doi.org/10.1111/1751-7915.14217 |
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author | Li, Linlin Zhong, Qiu Zhao, Yunze Bao, Juan Liu, Bing Zhong, Zhuojun Wang, Jing Yang, Lan Zhang, Tingting Cheng, Mengjun Wu, Nannan Zhu, Tongyu Le, Shuai |
author_facet | Li, Linlin Zhong, Qiu Zhao, Yunze Bao, Juan Liu, Bing Zhong, Zhuojun Wang, Jing Yang, Lan Zhang, Tingting Cheng, Mengjun Wu, Nannan Zhu, Tongyu Le, Shuai |
author_sort | Li, Linlin |
collection | PubMed |
description | A double‐stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin‐producing Pseudomonas aeruginosa strain, which was isolated from a 40‐year‐old man with interstitial lung disease (ILD) and chronic lung infection. Phage therapy was used as a last resort for this patient. The three‐course nebulized phiYY treatment was used to reduce the bacterial burden and clinical symptoms of the patient. Recurrences of P. aeruginosa infections were observed 1–3 days post phage therapy. The recurrent isolates exhibited distinct antibiotic‐susceptibility profiles compared with the original strain yet were still susceptible to phiYY. This assay represents the application of dsRNA phage in the treatment of chronic lung infection, albeit the safety and efficacy of the dsRNA phage require further assessment. |
format | Online Article Text |
id | pubmed-10034620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100346202023-03-24 First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection Li, Linlin Zhong, Qiu Zhao, Yunze Bao, Juan Liu, Bing Zhong, Zhuojun Wang, Jing Yang, Lan Zhang, Tingting Cheng, Mengjun Wu, Nannan Zhu, Tongyu Le, Shuai Microb Biotechnol Brief Report A double‐stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin‐producing Pseudomonas aeruginosa strain, which was isolated from a 40‐year‐old man with interstitial lung disease (ILD) and chronic lung infection. Phage therapy was used as a last resort for this patient. The three‐course nebulized phiYY treatment was used to reduce the bacterial burden and clinical symptoms of the patient. Recurrences of P. aeruginosa infections were observed 1–3 days post phage therapy. The recurrent isolates exhibited distinct antibiotic‐susceptibility profiles compared with the original strain yet were still susceptible to phiYY. This assay represents the application of dsRNA phage in the treatment of chronic lung infection, albeit the safety and efficacy of the dsRNA phage require further assessment. John Wiley and Sons Inc. 2023-01-13 /pmc/articles/PMC10034620/ /pubmed/36636832 http://dx.doi.org/10.1111/1751-7915.14217 Text en © 2023 The Authors. Microbial Biotechnology published by Applied Microbiology International and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Li, Linlin Zhong, Qiu Zhao, Yunze Bao, Juan Liu, Bing Zhong, Zhuojun Wang, Jing Yang, Lan Zhang, Tingting Cheng, Mengjun Wu, Nannan Zhu, Tongyu Le, Shuai First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection |
title | First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection |
title_full | First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection |
title_fullStr | First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection |
title_full_unstemmed | First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection |
title_short | First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection |
title_sort | first‐in‐human application of double‐stranded rna bacteriophage in the treatment of pulmonary pseudomonas aeruginosa infection |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034620/ https://www.ncbi.nlm.nih.gov/pubmed/36636832 http://dx.doi.org/10.1111/1751-7915.14217 |
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