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RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer
Tumors with mutations in chromatin regulators present attractive targets for DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) therapy, which further disrupts cancer cells’ epigenomic fidelity and reactivates transposable element (TE) expression to drive viral mimicry responses. SETD2 encodes a...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034851/ https://www.ncbi.nlm.nih.gov/pubmed/36662621 http://dx.doi.org/10.1016/j.celrep.2023.112016 |