RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer

Tumors with mutations in chromatin regulators present attractive targets for DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) therapy, which further disrupts cancer cells’ epigenomic fidelity and reactivates transposable element (TE) expression to drive viral mimicry responses. SETD2 encodes a...

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Detalles Bibliográficos
Autores principales: Li, Hong-Tao, Jang, H. Josh, Rohena-Rivera, Krizia, Liu, Minmin, Gujar, Hemant, Kulchycki, Justin, Zhao, Shuqing, Billet, Sandrin, Zhou, Xinyi, Weisenberger, Daniel J., Gill, Inderbir, Jones, Peter A., Bhowmick, Neil A., Liang, Gangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034851/
https://www.ncbi.nlm.nih.gov/pubmed/36662621
http://dx.doi.org/10.1016/j.celrep.2023.112016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034851/
https://www.ncbi.nlm.nih.gov/pubmed/36662621
http://dx.doi.org/10.1016/j.celrep.2023.112016

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