A Robust and Scalable Process for the Synthesis of Substantially Pure Clarithromycin 9-(E)-Oxime with an Established Control of the (Z)-Isomer Impurity

[Image: see text] Controlling the isomeric impurity in a key raw material is always critical to achieve the corresponding pure isomer-free targeted active pharmaceutical ingredient (API) in downstream processing. Clarithromycin 9-(E)-oxime is the key raw material for the synthesis of the 9a-lactam m...

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Detalles Bibliográficos
Autores principales: Chaudhari, Kiran, Gohar, Anil, Claerhout, Stijn, Ganorkar, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034979/
https://www.ncbi.nlm.nih.gov/pubmed/36969464
http://dx.doi.org/10.1021/acsomega.2c08207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034979/
https://www.ncbi.nlm.nih.gov/pubmed/36969464
http://dx.doi.org/10.1021/acsomega.2c08207

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