Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer

SH2 containing protein tyrosine phosphatase-2 (SHP2) is recognized as a druggable oncogenic phosphatase that is expressed in both tumor cells and immune cells. How tumor cell–autonomous SHP2 contributes to an immunosuppressive tumor microenvironment (TME) and therapeutic failure of immune checkpoint...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Cresswell, Gregory M., Libring, Sarah, Ayers, Mitchell G., Miao, Jinmin, Zhang, Zhong-Yin, Solorio, Luis, Ratliff, Timothy L., Wendt, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035406/
https://www.ncbi.nlm.nih.gov/pubmed/36969745
http://dx.doi.org/10.1158/2767-9764.CRC-22-0117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035406/
https://www.ncbi.nlm.nih.gov/pubmed/36969745
http://dx.doi.org/10.1158/2767-9764.CRC-22-0117

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