The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma

The TP63 gene encodes the p63 transcription factor. It is frequently amplified or overexpressed in squamous cell carcinomas. Owing to alternative splicing, p63 has multiple isoforms called α, β, γ, and δ. The regulatory functions of p63 are isoform specific. The α isoform inhibits the epithelial-to-...

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Detalles Bibliográficos
Autores principales: Taylor, William, Deschamps, Stéphane, Reboutier, David, Paillard, Luc, Méreau, Agnès, Audic, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035508/
https://www.ncbi.nlm.nih.gov/pubmed/36970727
http://dx.doi.org/10.1158/2767-9764.CRC-22-0350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035508/
https://www.ncbi.nlm.nih.gov/pubmed/36970727
http://dx.doi.org/10.1158/2767-9764.CRC-22-0350

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