Cargando…

The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma

The TP63 gene encodes the p63 transcription factor. It is frequently amplified or overexpressed in squamous cell carcinomas. Owing to alternative splicing, p63 has multiple isoforms called α, β, γ, and δ. The regulatory functions of p63 are isoform specific. The α isoform inhibits the epithelial-to-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taylor, William, Deschamps, Stéphane, Reboutier, David, Paillard, Luc, Méreau, Agnès, Audic, Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035508/ https://www.ncbi.nlm.nih.gov/pubmed/36970727 http://dx.doi.org/10.1158/2767-9764.CRC-22-0350

Ejemplares similares

Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2
por: Keppetipola, Niroshika M., et al.
Publicado: (2016)

Analysis of splicing patterns by pyrosequencing
por: Méreau, Agnès, et al.
Publicado: (2009)

Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation
por: Tan, Lit-Yeen, et al.
Publicado: (2015)

Repression of Wnt/β-catenin response elements by p63 (TP63)
por: Katoh, Iyoko, et al.
Publicado: (2016)

TP63 isoform expression is linked with distinct clinical outcomes in cancer
por: Bankhead, Armand, et al.
Publicado: (2020)

Psd-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2
por: Zheng, Sika, et al.
Publicado: (2012)

PTBP1 mRNA isoforms and regulation of their translation
por: Arake de Tacca, Luisa M., et al.
Publicado: (2019)

Polypyrimidine tract binding proteins PTBP1 and PTBP2 interact with distinct proteins under splicing conditions
por: Pina, Jeffrey M., et al.
Publicado: (2022)

SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
por: Kim, Jung-Hyun, et al.
Publicado: (2021)

Neural Isoforms of Agrin Are Generated by Reduced PTBP1−RNA Interaction Network Spanning the Neuron−Specific Splicing Regions in AGRN
por: Bushra, Samira, et al.
Publicado: (2023)

MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF
por: Miao, Hui, et al.
Publicado: (2022)

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
por: Li, Qin, et al.
Publicado: (2014)

SRSF1 and PTBP1 Are trans-Acting Factors That Suppress the Formation of a CD33 Splicing Isoform Linked to Alzheimer’s Disease Risk
por: van Bergeijk, Petra, et al.
Publicado: (2019)

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma
por: Somerville, Tim D.D., et al.
Publicado: (2018)

Correction: The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
por: Li, Qin, et al.
Publicado: (2017)

Inactivation of the Celf1 Gene that Encodes an RNA-Binding Protein Delays the First Wave of Spermatogenesis in Mice
por: Cibois, Marie, et al.
Publicado: (2012)

Identification of CELF1 RNA targets by CLIP-seq in human HeLa cells
por: Le Tonquèze, Olivier, et al.
Publicado: (2016)

PTBP-dependent PSD-95 and CamKIIα alternative splicing in the lens
por: Frederikse, Peter, et al.
Publicado: (2014)

NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
por: Hegde, Ganapati V, et al.
Publicado: (2019)

TP63 Is Significantly Upregulated in Diabetic Kidney
por: Liang, Sitai, et al.
Publicado: (2021)

PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing
por: Liang, Xin, et al.
Publicado: (2018)

High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin
por: Wang, Zhi-na, et al.
Publicado: (2017)

The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression
por: Lan, Chungen, et al.
Publicado: (2022)

MDB-17. THE PTBP2 SPLICING FACTOR IS ESSENTIAL IN GROUP 3/4 MEDULLOBLASTOMA
por: Caisova, Veronika, et al.
Publicado: (2023)

IL-1β Inflammatory Cytokine-Induced TP63 Isoform ∆NP63α Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells
por: Mendoza-Rodríguez, Mónica G., et al.
Publicado: (2019)

PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells
por: Guo, Jihua, et al.
Publicado: (2015)

Expression of TP53 Isoforms p53β or p53γ Enhances Chemosensitivity in TP53(null) Cell Lines
por: Silden, Elisabeth, et al.
Publicado: (2013)

TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development
por: Yi, Mei, et al.
Publicado: (2020)

RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts
por: Li, Yang I., et al.
Publicado: (2015)

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
por: Calabretta, Sara, et al.
Publicado: (2015)

PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes
por: Zhu, Binglin, et al.
Publicado: (2023)

Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma
por: Huang, Yongsheng, et al.
Publicado: (2021)

The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation
por: Linares, Anthony J, et al.
Publicado: (2015)

The splicing regulator PTBP2 is an AID interacting protein and promotes binding of AID to switch region DNA
por: Nowak, Urszula, et al.
Publicado: (2010)

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
por: Georgilis, Athena, et al.
Publicado: (2018)

PTBP3 Induced Inhibition of Differentiation of Gastric Cancer Cells Through Alternative Splicing of Id1
por: Chen, Bin, et al.
Publicado: (2020)

Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1
por: Li, Nana, et al.
Publicado: (2020)

hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells
por: Feng, Shenglei, et al.
Publicado: (2022)

DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
por: Duchemin, Amandine, et al.
Publicado: (2021)

Mosaic TP63 variant and associated ectodermal dysplasia features
por: Chen, Vivien, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dsg36rulhtjnhhuat5bv3jsqc7