Inclusion of 4-1BB Costimulation Enhances Selectivity and Functionality of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells

Chimeric antigen receptor (CAR) T cell immunotherapy is emerging as a powerful strategy for cancer therapy; however, an important safety consideration is the potential for off-tumor recognition of normal tissue. This is particularly important as ligand-based CARs are optimized for clinical translati...

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Detalles Bibliográficos
Autores principales: Starr, Renate, Aguilar, Brenda, Gumber, Diana, Maker, Madeleine, Huard, Stephanie, Wang, Dongrui, Chang, Wen-Chung, Brito, Alfonso, Chiu, Vivian, Ostberg, Julie R., Badie, Benham, Forman, Stephen J., Alizadeh, Darya, Wang, Leo D., Brown, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035515/
https://www.ncbi.nlm.nih.gov/pubmed/36968221
http://dx.doi.org/10.1158/2767-9764.CRC-22-0185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035515/
https://www.ncbi.nlm.nih.gov/pubmed/36968221
http://dx.doi.org/10.1158/2767-9764.CRC-22-0185

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