Cargando…

A PRRX1 Signature Identifies TIM-3 and VISTA as Potential Immune Checkpoint Targets in a Subgroup of Microsatellite Stable Colorectal Cancer Liver Metastases

Disease recurrence and drug resistance are major challenges in the clinical management of patients with colorectal cancer liver metastases (CLM), and because tumors are generally microsatellite stable (MSS), responses to immune therapies are poor. The mesenchymal phenotype is overrepresented in trea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nygaard, Vigdis, Ree, Anne Hansen, Dagenborg, Vegar Johansen, Børresen-Dale, Anne-Lise, Edwin, Bjørn, Fretland, Åsmund Avdem, Grzyb, Krzysztof, Haugen, Mads H., Mælandsmo, Gunhild M., Flatmark, Kjersti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035516/ https://www.ncbi.nlm.nih.gov/pubmed/36968142 http://dx.doi.org/10.1158/2767-9764.CRC-22-0295

Ejemplares similares

Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer
por: Dagenborg, Vegar Johansen, et al.
Publicado: (2021)

Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases
por: Østrup, Olga, et al.
Publicado: (2017)

Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases
por: Dagenborg, Vegar Johansen, et al.
Publicado: (2020)

A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer
por: Høye, Eirik, et al.
Publicado: (2022)

T cell receptor repertoire sequencing reveals chemotherapy-driven clonal expansion in colorectal liver metastases
por: Høye, Eirik, et al.
Publicado: (2023)

Nuclear Legumain Activity in Colorectal Cancer
por: Haugen, Mads H., et al.
Publicado: (2013)

Correction: Nuclear Legumain Activity in Colorectal Cancer
por: Haugen, Mads H., et al.
Publicado: (2013)

The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications
por: Haugen, Mads H, et al.
Publicado: (2008)

Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors
por: Seip, Kotryna, et al.
Publicado: (2016)

Portal Vein Embolization Using N-Butyl Cyanoacrylate-Glue: What Impact Does a Central Vascular Plug Have?
por: Carling, Ulrik, et al.
Publicado: (2021)

Difficult procedures, better outcomes
por: Aghayan, Davit L., et al.
Publicado: (2023)

Open versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet study): study protocol for a randomized controlled trial
por: Fretland, Åsmund Avdem, et al.
Publicado: (2015)

A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases()
por: Flørenes, Vivi Ann, et al.
Publicado: (2019)

Till death do us part: the effect of marital status on health care utilization and costs at end-of-life. A register study on all colorectal cancer decedents in Norway between 2009 and 2013
por: Bjørnelv, Gudrun Maria Waaler, et al.
Publicado: (2020)

Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population‐based series and a randomized phase III study on adjuvant chemotherapy
por: Boye, Kjetil, et al.
Publicado: (2016)

Evolution of laparoscopic liver surgery: 20-year experience of a Norwegian high-volume referral center
por: Aghayan, Davit L., et al.
Publicado: (2021)

Cystatin E/M suppresses legumain activity and invasion of human melanoma
por: Briggs, Jon J, et al.
Publicado: (2010)

Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate
por: Ree, Anne Hansen, et al.
Publicado: (2017)

Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy
por: Bratland, Åse, et al.
Publicado: (2011)

Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, Multiplex Methods, Molecular Networks
por: Ree, Anne Hansen, et al.
Publicado: (2014)

Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers
por: Haugen, Mads H., et al.
Publicado: (2021)

Minimally Invasive Pancreatoduodenectomy: Contemporary Practice, Evidence, and Knowledge Gaps
por: Ghotbi, Jacob, et al.
Publicado: (2022)

Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells
por: Tamhane, Tripti, et al.
Publicado: (2015)

Basal‐like breast cancer engages tumor‐supportive macrophages via secreted factors induced by extracellular S100A4
por: Prasmickaite, Lina, et al.
Publicado: (2018)

The effect of intraoperative imaging on surgical navigation for laparoscopic liver resection surgery
por: Teatini, Andrea, et al.
Publicado: (2019)

Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer
por: Fleten, Karianne Giller, et al.
Publicado: (2021)

Generic surgical process model for minimally invasive liver treatment methods
por: Gholinejad, Maryam, et al.
Publicado: (2022)

Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening
por: Kalanxhi, Erta, et al.
Publicado: (2016)

Expression of Immune Checkpoint Regulators IDO, VISTA, LAG3, and TIM3 in Resected Pancreatic Ductal Adenocarcinoma
por: Popp, Felix C., et al.
Publicado: (2021)

Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer
por: Meltzer, Sebastian, et al.
Publicado: (2022)

miR-101-5p Acts as a Tumor Suppressor in HER2-Positive Breast Cancer Cells and Improves Targeted Therapy
por: Normann, Lisa Svartdal, et al.
Publicado: (2022)

PRRX1 promotes malignant properties in human osteosarcoma
por: Joko, Ryoji, et al.
Publicado: (2020)

Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer
por: Hektoen, Helga Helseth, et al.
Publicado: (2015)

Laparoscopic liver resection for non-colorectal non-neuroendocrine metastases: perioperative and oncologic outcomes
por: Aghayan, Davit L., et al.
Publicado: (2019)

EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer
por: Boye, K, et al.
Publicado: (2012)

Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer
por: Meltzer, Sebastian, et al.
Publicado: (2019)

Corrigendum to “Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer” [Transl Oncol 12 (8) (2019) 1038–1044]
por: Meltzer, Sebastian, et al.
Publicado: (2019)

The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
por: Du, Wenjiao, et al.
Publicado: (2021)

Site‐Specific Load‐Induced Expansion of Sca‐1(+)Prrx1(+) and Sca‐1(−)Prrx1(+) Cells in Adult Mouse Long Bone Is Attenuated With Age
por: Cabahug‐Zuckerman, Pamela, et al.
Publicado: (2019)

Tumor kinase activity in locally advanced rectal cancer: angiogenic signaling and early systemic dissemination
por: Saelen, Marie Grøn, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_i624qvthg5lgasl2c0h9qvu884