Amino acid substitutions in human growth hormone affect secondary structure and receptor binding

The interaction between human Growth Hormone (hGH) and hGH Receptor (hGHR) has basic relevance to cancer and growth disorders, and hGH is the scaffold for Pegvisomant, an anti-acromegaly therapeutic. For the latter reason, hGH has been extensively engineered by early workers to improve binding and o...

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Detalles Bibliográficos
Autores principales: Rajkovic, Andrei, Kanchugal, Sandesh, Abdurakhmanov, Eldar, Howard, Rebecca, Wärmländer, Sebastian, Erwin, Joseph, Barrera Saldaña, Hugo A., Gräslund, Astrid, Danielson, Helena, Flores, Samuel Coulbourn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035860/
https://www.ncbi.nlm.nih.gov/pubmed/36952491
http://dx.doi.org/10.1371/journal.pone.0282741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035860/
https://www.ncbi.nlm.nih.gov/pubmed/36952491
http://dx.doi.org/10.1371/journal.pone.0282741

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