MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism

Bone homeostasis is regulated by hormones such as parathyroid hormone (PTH). While PTH can stimulate osteo-progenitor expansion and bone synthesis, how the PTH-signaling intensity in progenitors is controlled is unclear. Endochondral bone osteoblasts arise from perichondrium-derived osteoprogenitors...

Descripción completa

Detalles Bibliográficos
Autores principales: Chu, Tsz Long, Chen, Peikai, Yu, Anna Xiaodan, Kong, Mingpeng, Tan, Zhijia, Tsang, Kwok Yeung, Zhou, Zhongjun, Cheah, Kathryn Song Eng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036123/
https://www.ncbi.nlm.nih.gov/pubmed/36892459
http://dx.doi.org/10.7554/eLife.82142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036123/
https://www.ncbi.nlm.nih.gov/pubmed/36892459
http://dx.doi.org/10.7554/eLife.82142

Ejemplares similares