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MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism

Bone homeostasis is regulated by hormones such as parathyroid hormone (PTH). While PTH can stimulate osteo-progenitor expansion and bone synthesis, how the PTH-signaling intensity in progenitors is controlled is unclear. Endochondral bone osteoblasts arise from perichondrium-derived osteoprogenitors...

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Detalles Bibliográficos
Autores principales:	Chu, Tsz Long, Chen, Peikai, Yu, Anna Xiaodan, Kong, Mingpeng, Tan, Zhijia, Tsang, Kwok Yeung, Zhou, Zhongjun, Cheah, Kathryn Song Eng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036123/ https://www.ncbi.nlm.nih.gov/pubmed/36892459 http://dx.doi.org/10.7554/eLife.82142

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