Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia

Chimeric antigen receptor (CAR)-T cell therapies have shown tremendous results against various hematologic cancers. Prior to cell infusion, a host preconditioning regimen is required to achieve lymphodepletion and improve CAR-T cell pharmacokinetic exposure, leading to greater chances of therapeutic...

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Detalles Bibliográficos
Autores principales: Derippe, Thibaud, Fouliard, Sylvain, Marchiq, Ibtissam, Dupouy, Sandra, Almena-Carrasco, Maria, Geronimi, Julia, Declèves, Xavier, Chenel, Marylore, Mager, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036133/
https://www.ncbi.nlm.nih.gov/pubmed/36970053
http://dx.doi.org/10.1158/2767-9764.CRC-22-0176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036133/
https://www.ncbi.nlm.nih.gov/pubmed/36970053
http://dx.doi.org/10.1158/2767-9764.CRC-22-0176

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