Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors

Synthetic anticancer catalysts offer potential for low-dose therapy and the targeting of biochemical pathways in novel ways. Chiral organo-osmium complexes, for example, can catalyse the asymmetric transfer hydrogenation of pyruvate, a key substrate for energy generation, in cells. However, small-mo...

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Detalles Bibliográficos
Autores principales: Bridgewater, Hannah E., Bolitho, Elizabeth M., Romero-Canelón, Isolda, Sadler, Peter J., Coverdale, James P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036267/
https://www.ncbi.nlm.nih.gov/pubmed/36884092
http://dx.doi.org/10.1007/s00775-023-01994-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036267/
https://www.ncbi.nlm.nih.gov/pubmed/36884092
http://dx.doi.org/10.1007/s00775-023-01994-3

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