Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells

AIMS/HYPOTHESIS: Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of human INS mRNA in pancreatic islets. METHODS: Alternative splicing of insulin pre-mRNA was determined by PCR analysis performed on human islet RNA a...

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Detalles Bibliográficos
Autores principales: van Tienhoven, René, Kracht, Maria J. L., van der Slik, Arno R., Thomaidou, Sofia, Wolters, Anouk H. G., Giepmans, Ben N. G., Riojas, Juan Pablo Romero, Nelson, Michael S., Carlotti, Françoise, de Koning, Eelco J. P., Hoeben, Rob C., Zaldumbide, Arnaud, Roep, Bart O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036285/
https://www.ncbi.nlm.nih.gov/pubmed/36884057
http://dx.doi.org/10.1007/s00125-023-05882-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036285/
https://www.ncbi.nlm.nih.gov/pubmed/36884057
http://dx.doi.org/10.1007/s00125-023-05882-y

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