Two gates mediate NMDA receptor activity and are under subunit-specific regulation

Kinetics of NMDA receptor (NMDAR) ion channel opening and closing contribute to their unique role in synaptic signaling. Agonist binding generates free energy to open a canonical gate at the M3 helix bundle crossing. Single channel activity is characterized by clusters, or periods of rapid opening a...

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Detalles Bibliográficos
Autores principales: Amin, Johansen B., He, Miaomiao, Prasad, Ramesh, Leng, Xiaoling, Zhou, Huan-Xiang, Wollmuth, Lonnie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036335/
https://www.ncbi.nlm.nih.gov/pubmed/36959168
http://dx.doi.org/10.1038/s41467-023-37260-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036335/
https://www.ncbi.nlm.nih.gov/pubmed/36959168
http://dx.doi.org/10.1038/s41467-023-37260-y

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