Cargando…

Two gates mediate NMDA receptor activity and are under subunit-specific regulation

Kinetics of NMDA receptor (NMDAR) ion channel opening and closing contribute to their unique role in synaptic signaling. Agonist binding generates free energy to open a canonical gate at the M3 helix bundle crossing. Single channel activity is characterized by clusters, or periods of rapid opening a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amin, Johansen B., He, Miaomiao, Prasad, Ramesh, Leng, Xiaoling, Zhou, Huan-Xiang, Wollmuth, Lonnie P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036335/ https://www.ncbi.nlm.nih.gov/pubmed/36959168 http://dx.doi.org/10.1038/s41467-023-37260-y

Ejemplares similares

Subunit-specific Contribution of Pore-forming Domains to NMDA Receptor Channel Structure and Gating
por: Sobolevsky, Alexander I., et al.
Publicado: (2007)

A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca(2+) permeability
por: Amin, Johansen B., et al.
Publicado: (2018)

Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit
por: He, Miaomiao, et al.
Publicado: (2023)

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening
por: Talukder, Iehab, et al.
Publicado: (2011)

Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents
por: Kazi, Rashek, et al.
Publicado: (2014)

Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors
por: Amin, Johansen B., et al.
Publicado: (2017)

Prying open a glutamate receptor gate
por: Wollmuth, Lonnie P.
Publicado: (2019)

Differential regulation of tetramerization of the AMPA receptor glutamate–gated ion channel by auxiliary subunits
por: Certain, Noele, et al.
Publicado: (2023)

Different Mechanisms of Ca(2+) Transport in NMDA and Ca(2+)-permeable AMPA Glutamate Receptor Channels
por: Wollmuth, Lonnie P., et al.
Publicado: (1998)

A Swiss army knife for targeting receptors
por: Amin, Johansen B, et al.
Publicado: (2018)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

Cross-subunit interactions that stabilize open states mediate gating in NMDA receptors
por: Iacobucci, Gary J., et al.
Publicado: (2021)

Specific Roles of NMDA Receptor Subunits in Mental Disorders
por: Yamamoto, H., et al.
Publicado: (2015)

The structure-energy landscape of NMDA Receptor gating
por: Dolino, Drew M., et al.
Publicado: (2017)

Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
por: Chan, Kelvin, et al.
Publicado: (2020)

NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina
por: Bai, Ning, et al.
Publicado: (2013)

Role of Cross-Cleft Contacts in NMDA Receptor Gating
por: Paganelli, Meaghan A., et al.
Publicado: (2013)

Cocaine-induced Changes in the Expression of NMDA Receptor Subunits
por: Smaga, Irena, et al.
Publicado: (2019)

Acetylcholine Receptor Gating: Movement in the α-Subunit Extracellular Domain
por: Purohit, Prasad, et al.
Publicado: (2007)

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit
por: Hilary Yong, Xuan Ling, et al.
Publicado: (2021)

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney
por: Valdivielso, José M., et al.
Publicado: (2020)

The pre-M1 helix controls NMDA receptor gating
por: Short, Ben
Publicado: (2020)

NMDA receptor structures reveal subunit arrangement and pore architecture
por: Lee, Chia-Hsueh, et al.
Publicado: (2014)

Extracellular Ca(2+) ions reduce NMDA receptor conductance and gating
por: Maki, Bruce A., et al.
Publicado: (2014)

NMDA receptor channel gating control by the pre-M1 helix
por: McDaniel, Miranda J., et al.
Publicado: (2020)

Olanzapine Reverses MK-801-Induced Cognitive Deficits and Region-Specific Alterations of NMDA Receptor Subunits
por: Liu, Xiao, et al.
Publicado: (2018)

Mechanism of differential control of NMDA receptor activity by NR2 subunits
por: Gielen, Marc, et al.
Publicado: (2009)

Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
por: Schmitt, Andrea, et al.
Publicado: (2009)

Influence of GluN2 subunit identity on NMDA receptor function
por: Wyllie, D.J.A., et al.
Publicado: (2013)

A structurally derived model of subunit‐dependent NMDA receptor function
por: Gibb, Alasdair J., et al.
Publicado: (2018)

Cognitive Flexibility in Mice: Effects of Puberty and Role of NMDA Receptor Subunits
por: Seifried, Lisa, et al.
Publicado: (2023)

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators
por: France, G., et al.
Publicado: (2022)

Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice
por: Bigini, Paolo, et al.
Publicado: (2006)

Evolutionary Mode and Functional Divergence of Vertebrate NMDA Receptor Subunit 2 Genes
por: Teng, Huajing, et al.
Publicado: (2010)

Plasticity of NMDA receptor NR2B subunit in memory and chronic pain
por: Zhuo, Min
Publicado: (2009)

GluN3A: An NMDA Receptor Subunit with Exquisite Properties and Functions
por: Kehoe, Laura A., et al.
Publicado: (2013)

Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia
por: Vinnakota, Chitra, et al.
Publicado: (2023)

PS126. DAPK1 interaction with NMDA receptor NR2B subunit underlies the rapid antidepressant effect
por: Xu, Ling-Zhi, et al.
Publicado: (2016)

Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines
por: Stein, Ivar S., et al.
Publicado: (2021)

Acute 5-HT7 receptor activation increases NMDA-evoked currents and differentially alters NMDA receptor subunit phosphorylation and trafficking in hippocampal neurons
por: Vasefi, Maryam S, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_t5aqpg8t4phhru4450k89oncmc