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Physiologically Based Pharmacokinetic Model of Brain Delivery of Plasma Protein Bound Drugs
INTRODUCTION: A physiologically based pharmacokinetic (PBPK) model is developed that focuses on the kinetic parameters of drug association and dissociation with albumin, alpha-1 acid glycoprotein (AGP), and brain tissue proteins, as well as drug permeability at the blood–brain barrier, drug metaboli...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer US
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036418/ https://www.ncbi.nlm.nih.gov/pubmed/36829100 http://dx.doi.org/10.1007/s11095-023-03484-2 |