IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics

We have investigated the dynamics of two [Formula: see text] -immunoglobulin molecules, IgG1 and IgG4, using long all atom molecular dynamics simulations. We first show that the de novo structures of IgG1 and IgG4 predicted using AlphaFold, with no interactions between the fragment crystallizable (F...

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Detalles Bibliográficos
Autores principales: Natesan, Ramakrishnan, Agrawal, Neeraj J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036467/
https://www.ncbi.nlm.nih.gov/pubmed/36959284
http://dx.doi.org/10.1038/s41598-023-32067-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036467/
https://www.ncbi.nlm.nih.gov/pubmed/36959284
http://dx.doi.org/10.1038/s41598-023-32067-9

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