GFAP and NfL increase during neurotoxicity from high baseline levels in pediatric CD19-CAR T-cell patients

There is a need for biomarkers to predict and measure the severity of immune effector cell–associated neurotoxicity syndrome (ICANS). Glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) are well-validated biomarkers of astroglial and neuronal injury, respectively. We hypothesi...

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Detalles Bibliográficos
Autores principales: Gust, Juliane, Rawlings-Rhea, Stephanie D., Wilson, Ashley L., Tulberg, Niklas M., Sherman, Amber L., Seidel, Kristy D., Wu, Qian “Vicky”, Park, Julie R., Gardner, Rebecca A., Annesley, Colleen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036503/
https://www.ncbi.nlm.nih.gov/pubmed/36006611
http://dx.doi.org/10.1182/bloodadvances.2022008119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036503/
https://www.ncbi.nlm.nih.gov/pubmed/36006611
http://dx.doi.org/10.1182/bloodadvances.2022008119

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