A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant

Upon systemic administration, adeno-associated virus serotype 9 (AAV9) and the capsid variant PHP.eB show distinct tropism for the central nervous system (CNS), whereas AAV2 and the capsid variant BR1 transduce brain microvascular endothelial cells (BMVECs) with little transcytosis. Here, we show th...

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Detalles Bibliográficos
Autores principales: Kawabata, Hayato, Konno, Ayumu, Matsuzaki, Yasunori, Hirai, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036519/
https://www.ncbi.nlm.nih.gov/pubmed/36970652
http://dx.doi.org/10.1016/j.omtm.2023.02.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036519/
https://www.ncbi.nlm.nih.gov/pubmed/36970652
http://dx.doi.org/10.1016/j.omtm.2023.02.016

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