Napabucasin plus nab-paclitaxel with gemcitabine versus nab-paclitaxel with gemcitabine in previously untreated metastatic pancreatic adenocarcinoma: an adaptive multicentre, randomised, open-label, phase 3, superiority trial

BACKGROUND: Compared with normal cells, tumour cells contain elevated levels of reactive oxygen species (ROS). Increased levels of the antioxidant protein NAD(P)H:quinone oxidoreductase 1 (NQO1) and phosphorylated signal transducer and activator of transcription 3 (pSTAT3) correlate negatively with...

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Detalles Bibliográficos
Autores principales: Bekaii-Saab, Tanios, Okusaka, Takuji, Goldstein, David, Oh, Do-Youn, Ueno, Makoto, Ioka, Tatsuya, Fang, Weijia, Anderson, Eric C., Noel, Marcus S., Reni, Michele, Choi, Hye Jin, Goldberg, Jonathan S., Oh, Sang Cheul, Li, Chung-Pin, Tabernero, Josep, Li, Jian, Foos, Emma, Oh, Cindy, Van Cutsem, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036520/
https://www.ncbi.nlm.nih.gov/pubmed/36969338
http://dx.doi.org/10.1016/j.eclinm.2023.101897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036520/
https://www.ncbi.nlm.nih.gov/pubmed/36969338
http://dx.doi.org/10.1016/j.eclinm.2023.101897

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