ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias

Deletion of ABL1 was detected in a cohort of hematologic malignancies carrying AML1-ETO and NUP98 fusion proteins. Abl1−/− murine hematopoietic cells transduced with AML1-ETO and NUP98-PMX1 gained proliferation advantage when compared to Abl1 + /+ counterparts. Conversely, overexpression and pharmac...

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Detalles Bibliográficos
Autores principales: Golovine, Konstantin, Abalakov, Gleb, Lian, Zhaorui, Chatla, Srinivas, Karami, Adam, Chitrala, Kumaraswamy Naidu, Madzo, Jozef, Nieborowska-Skorska, Margaret, Huang, Jian, Skorski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036529/
https://www.ncbi.nlm.nih.gov/pubmed/36959186
http://dx.doi.org/10.1038/s41408-023-00810-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036529/
https://www.ncbi.nlm.nih.gov/pubmed/36959186
http://dx.doi.org/10.1038/s41408-023-00810-0

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